Serum acid phosphatase activity in diabetes mellitus.

Lysosomal enzymes acid phosphatase show increase in diabetes mellitus and this is closely related to diabetic metabolic alterations. This was a crosssectional study conducted on 50 diabetic subjects (25 patients with complications and 25 patients without complications) in RIMS hospital during the period from September 2010 to August 2012. Twenty five age and sex matched healthy individual were taken as controls. Glycosylated haemoglobin (HbA1c) was estimated by Fast Ion Exchange Resin Method. Acid Phosphatase was estimated by colorimetric kit method. The difference in the level of Fasting Blood Sugar(FBS), Postprandial Blood Sugar(PPBS) and HbA1c between control, diabetic groups without and diabetes with complication groups was significant statistically (P<0.001) indicating a poor control of glucose in the study group. There was a significant difference in the level of Acid Phosphatase in control, diabetic group without complication and diabetes with complication(2.03±0.73, 4.58±0.68, 8.61±1.05IU/L) respectively. The comparison of serum acid phosphatase level in male and female subjects in the study groups was insignificant. Statistically significant increase in serum acid phosphatase level was observed in the diabetes with complication compared to those without the complication (P <0.001). There was a significant positive correlation of acid phosphatase with fasting blood sugar, postprandial blood sugar and glycosylated haemoglobin. Acid phosphatase can be used as an index for the development, control of diabetes and prognosis of diabetic complications.